What are the top HGH injections on the market?

There are only a few medications that the Food and Drug Administration (FDA) has approved for the treatment of adult human growth hormone deficiency (GHD).

Let’s survey four of the most commonly utilized HGH injections and what the research says about how they work. Each of these products works by supplementing the body’s natural supply of human growth hormone with a synthetic form of human HGH.


Manufactured by Novo Nordisk, Norditropin, has been used for decades. A wealth of clinical research has borne out the effectiveness of Norditropin in both children and adults diagnosed with GHD.

Portable Norditropin injection pens, such as the Nordiflex, make HGH injections easy. One study from Patient Preference and Adherence found that the injection pen improved patient adherence to growth hormone therapy protocols due to ease of use:

“This study has shown that Norditropin NordiFlex is reliable, safe, and easy to use and most study patients preferred it to their previous device. These characteristics may improve the adherence to GHT.”

Men who have recently had stomach surgery, experienced trauma, or had breathing issues should not receive Norditropin. Also, if you have a history of cancer or diabetes, Norditropin may not be right for you.

Norditropin might interact with certain medications or supplements. It’s important to tell your doctor about all medications or supplements you are currently taking to avoid any negative drug interactions.

Norditropin injection pens are designed for maximum efficiency and ease of use. They are easily transportable. Products like the FlexPro® pen come preloaded and prefilled – all you have to do is make a few clicks and do the injection. It all takes a matter of a minute once you get the routine down.

Here’s a quick guide from Novo Nordisk:

Visit the official website to learn more about Norditropin, its benefits and risks, and how it has helped men recover from GHD.

Here’s what Ken, 56, has to say about his experience with Norditropin:

``I was constantly tired and my performance in the gym had been lagging pretty seriously for a few years. I tried other supplements and a few medications based on my primary doc's recommendations, but they never solved the issue. It wasn't until I visited HGH For Men Clinic and got properly diagnosed with an HGH deficiency that I started taking Norditropin. Flash forward a few months and I'm back and better than ever. My sleep is right, my gym performance is back, and I feel more energetic than I have in years.``

Ken, 56 y.o.


Omnitrope is manufactured by Sandoz. It earned FDA approval in 2006 to treat growth hormone deficiency. It’s one of the most widely used formulations of somatropin (recombinant human growth hormone) in the United States.

It’s indicated for adults, in particular, experiencing GHD. It’s also, like other forms of somatropin, designed for subcutaneous injection.

Therapy requires weekly injections spaced out over a period of 6 to 7 days.

The starting dose is generally 0.04 mg/kg/week. It can be increased to not more than 0.08 mg/kg/week by your physician depending on how your body responds to the initial starting dose.

Omnitrope is available as both injection pens and vial and syringe. For the injection pens, it is packaged as OMNITROPE® Cartridge 5 mg/1.5 mL or OMNITROPE® Cartridge 10 mg/1.5 mL.

For vial and syringe, it’s packaged as a 5.8 mg/vial and another vial solution that contains a diluent.

Side effects from Omnitrope are rare. The most common ones are injection site reactions and headaches. Your doctor can help to titrate your dose to reap the maximum benefits from therapy while minimizing side effects.

Omnitrope might interact with insulin, glucocorticoid replacement therapy, and oral estrogen.

Here’s what Lacey, 42, says about his experience with Omnitrope:

``In 2020, I had this mental fog and depression that wouldn't clear up no matter how hard I worked out or how clean I ate or how long I slept. I went from doctor to doctor and website to website looking for the cause, to no avail. Then a friend recommended that I visit HGH For Men Clinic to investigate a possible hormone issue, and my doc discovered an HGH deficiency through lab testing. He put me on an Omnitrope regimen. Within about six months, my cognition had improved markedly. Plus my sex life is way better.``

Lacey, 42 y.o.


Genotropin, manufactured by Pfizer, gained FDA approval in 2001 for the treatment of growth hormone deficiency as recombinant human growth hormone (rHGH).

The starting dose by weight is 0.04 mg/kg/week. Your doctor may incrementally increase the dose to 0.08 mg/kg/week as your progress through therapy.

Genotropin injection pens come in the form of 5 mg (green tip) and 12 mg (purple tip) (with preservative). For the vial and syringe, the product comes packaged as 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 1.0 mg, 1.2 mg, 1.4 mg, 1.6 mg, 1.8 mg, and 2.0 mg.

Genotropin might interact with certain medications. Ask your doctor about any potential negative interactions before beginning therapy.

Genotropin is generally free of side effects, although some such as fluid retention and carpal tunnel syndrome may occur.

Multiple clinical studies have demonstrated Genotropin’s efficacy for safely elevating HGH levels in adults with diagnosed deficiencies.

Here’s what Stanley, 55, says about his experience with Genotropin:

``My wife and I of 25 years enjoy a robust sex life. A few years ago, my libido began to fade and I had some issues with erectile dysfunction as well. I chalked it up to part of the normal aging, but my doctor referred me to HGH For Men Clinic to see if my issue might be related to hormones. After a consultation and some testing, we found that my HGH levels were in the tank, as was my testosterone. We got on simultaneous HGH replacement therapy and testosterone replacement therapy. Within a short period, I was back to feeling like my old frisky self. My wife I think is even happier about the results than I am.``

Stanley, 55 y.o.


Saizen, manufactured by Merck, is FDA-approved to treat adult growth hormone deficiency.

Saizen side effects are usually mild and easily managed. Serious side effects are rare. Patients with a history of diabetes or cancer should not receive therapy with Saizen.

The product comes in either 5 or 8.8 mg vials. Other ingredients include sucrose, benzyl alcohol, and O-phosphoric acid.

The click.easy® product from Saizen is a patented injection device that makes administration safer, easier, and more pain-free than traditional methods using a vial and syringe.

Here is a brief instructional video on how to use the click.easy® device:

Clinical data shows that Saizen is an effective exogenous substitute for endogenous human growth hormone, and performs the same type of signaling work that naturally occurring HGH does.

Saizen is particularly beneficial for boosting men’s lean body mass (muscle mass). For instance, in a study cited in the FDA’s document approving Saizen, researchers found the following results:

“A multicenter, randomized, double-blind, placebo-controlled clinical trial was conducted in 115 adults with GHD comparing the effects of Saizen® [somatropin (rDNA origin) for injection] and placebo on body composition. Patients in the active treatment arm were treated with Saizen® at an initial dose of 0.005 mg/kg/day for one month which was increased to 0.01 mg/kg/day if tolerated for the remaining five months of the study. The primary endpoint was the change from baseline in lean body mass (LBM) measured by dual energy X-ray absorptiometry (DXA) after 6 months. Treatment with Saizen® produced significant (p<0.001) increases from baseline in LBM compared to placebo (Table 1).”

Here’s what Greg, 60, says about his experience with Saizen:

``The first sign that something was off was my hair and skin. They somehow lost their natural luster that I had taken so much pride in earlier on in my life. I also noticed that my memory had begun to fade a little bit, but I didn't make the connection. After discussing my symptoms with my doctor, he wondered if I had done any hormone testing. I said no – in fact, I had never even thought about the possibility. Some time passed by and the symptoms got worse, so I finally scheduled a consultation with HGH For Men Clinic out of desperation, not expecting much. Boy, was I wrong about that! I can safely say that HGH therapy with Saizen has done miracles!``

Greg, 60 y.o.

What are the benefits of HGH injections?

The mechanism by which HGH injections work is by increasing the supply of human growth hormone in the blood. Normally, the pituitary gland in the brain produces and releases enough HGH to meet the body’s demand for the hormone.

However, GHD patients do not have enough endogenous HGH in their blood, which results in symptoms such as unwanted fat gain, chronic fatigue, muscle loss, and mental health conditions, among many more negative health outcomes. That’s where pharmaceutical supplementation comes into play to make up the difference.

Research shows multiple mental and physical health benefits from using the HGH injections to correct GHD. These include:

  • Boosted energy levels
  • Restored libido (sex drive)
  • Reduced anxiety and depression
  • Greater focus and memory
  • Sleeker, younger-looking skin, hair, and nails
  • Speedier metabolism for weight loss
  • Optimized athletic performance (increased muscle gains and better endurance)
  • Improved sleep quality
  • Strengthened bones
  • Decreased blood pressure
  • Fuller, thicker hair
  • Lower stress levels

What are the side effects of HGH injections?

There are some side effects of HGH injections. It’s important to note that your doctor (endocrinologist) can help to eliminate or mitigate these by adjusting the dose and administrative schedule as well as other aspects of your regimen.

Common HGH side effects include:

  • carpal tunnel syndrome
  • enlargement of breast tissue (gynecomastia)
  • swelling in the arms and legs (edema)
  • increased risk of certain cancers
  • joint swelling
  • joint pain
  • increased risk of diabetes

Patients with cancer, diabetes, past trauma, breathing issues, and women who are pregnant or breastfeeding should not take HGH injections. In some cases, HGH might trigger a dangerous autoimmune response, so patients who have a history of autoimmune illness should be monitored carefully.

side effects of gh therapy include joint pain
hgh therapy may increase diabetes risk

What is the difference between HGH releasers and synthetic HGH injections?

There are important differences between HGH injections and so-called “HGH releasers.” HGH releasers are sometimes known as “HGH boosters.”

Rather than containing synthetic HGH (somatropin), HGH releasers are most commonly pills or other supplements, and sometimes intravenous injections, designed for oral administration that induce HGH secretion in humans, usually containing some combination of amino acids and other ingredients:

“Specific amino acids, such as arginine, lysine and ornithine, can stimulate growth hormone (GH) release when infused intravenously or administered orally.”

Most HGH releasers sold on the web are not approved for use to treat GHD by the US Food and Drug Administration.

At HGH For Men Clinic, we also provide patients with Sermorelin, an HGH releaser.

Sermorelin acetate, originally manufactured by EMD Serono, was approved by the FDA in 1997 to treat growth hormone deficiency. It works as a peptide analog of growth hormone-releasing hormone (GHRH).

Rather than replacing circulating HGH, Sermorelin stimulates the pituitary gland, which results in greater secretion of natural HGH. Replacement therapy with Sermorelin may be used independently or in combination with somatropin to elevate HGH levels.

Most patients tolerate Sermorelin well. However, there is more evidence that somatropin effectively raises HGH levels over the long term.

HGH Supplements vs Injections

HGH injections are the gold standard for boosting HGH levels.

There are also products on the market called HGH supplements, which advertisers claim raise HGH levels. Popular HGH supplements include SeroVital, ProBLEN, and Growth Factor 9 (GF-9).

Let’s explore a chart breaking down the ingredients, efficacy, and benefits of both options.

HGH supplements HGH injections
Ingredients Schizopeneta (which may cause liver damage), amino acids, somatropin
FDA-approved? No Yes
Clinical testing to prove efficacy? No Yes
Prescription required? No Yes
Safety testing? No Yes
Proven benefits? None Improved energy, muscle gain, fat loss, cognitive optimization, improved mood, cleaner sleep, and more


Here’s what the Mayo Clinic says about HGH supplements vs HGH injections:

“HGH is only effective if administered as an injection. There’s no pill form of human growth hormone available. Some dietary supplements that claim to boost levels of HGH come in pill form, but research doesn’t show a benefit.”

Because over-the-counter HGH supplements have not been proven through clinical testing to work, if you look carefully at the bottom of any HGH supplement label, you’ll find the following warning:

“These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.”

Let that warning be all the evidence you need to stick with proven medications like the ones we use at HGH For Men Clinic. Leave the scams for other non-informed patients.

HGH is only effective as an injection
GH therapy helps improve health in men of all ages

Where is the best place to find HGH injections for sale?

Patients should be very careful about where they purchase their HGH products. According to the World Health Organization, 10% of supplements purchased from Third World countries like China or India are either fake or substandard.

The only way to avoid low-quality, adulterated, or fake medical supplies is to purchase brand-name, FDA-approved formulations from respected manufacturers.

At HGH For Men Clinic, we only work with licensed pharmacies that utilize FDA-approved products. Talk to your doctor to learn more about how to avoid HGH scams to protect your health and your wallet.

When you have your prescription in hand and you’re ready to find a pharmacy, use the following tool: Locate a State-Licensed Online Pharmacy – FDA.


Here we’ll explore some of the more commonly asked questions regarding HGH injections for men.

Men with diagnosed growth hormone deficiency (GHD) are eligible to receive HGH injections. GHD is determined through blood tests.

HGH injections in the United States are legal with a valid prescription issued by a licensed doctor. It is illegal to buy, sell, or use HGH without a prescription.

No. There is no form of HGH injection that is available over the counter. A prescription is required to purchase HGH.

Get in touch

Please get in touch and our expert support team will answer all your questions about HGH therapy.

8199 West River Street

Brooklyn, New York 11224

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